claim to fame...
Crinagen is a completely natural topical scalp preparation. Its natural ingredients perform two basic functions: they decrease the production of a potent male hormone associated with male-pattern hair loss and affect the blood vessels that nourish
follicles in the scalp. One of the unique aspects of this treatment is that it does not have just one active ingredient; it has many. These ingredients act together to help block factors that are detrimental to
The ingredients are: Distilled water; Polysorbate 20; Azelaic Acid; Zinc
acetate hydrate; Niacin; Vitamin B6 (as Pyridoxal-5-phosphate); Saw
palmetto extract (serenoa repens); Ginkgo biloba and a mild natural
The two most powerful ingredients of are Zinc and Saw Palmetto. Both agents have been shown to block the conversion of male sex hormones (such as testosterone) into
dihydrotestosterone (DHT). Dihydrotestosterone is a potent hormone. Most researchers believe it is responsible for male-pattern
baldness. The ingredients accomplish this by blocking the enzyme 5 alpha-reductase, which is required to produce dihydrotestosterone. Since the ingredients
are all natural ones, there are no hormonal side effects. The hallmark of male-pattern
baldness is the progressive miniaturization of follicles. This is caused by a genetic predisposition of individual
follicles that renders them more sensitive to normal circulating levels of male sex hormones. This is because increased levels of 5 alpha-reductase in these follicles causes the conversion of male hormones (such as testosterone) into dihydrotestosterone.
DHT continues to damage and miniaturize follicles. As follicles are continually damaged by the ongoing effects of dihydrotestosterone, the body responds to this injury with an inflammatory response which is primarily mediated by the immune system. The cells of the immune system cause inflammatory reactions which further damage these
follicles and eventually destroy them.
The best way to stop the progression of androgenic
Alopecia is to correct the underlying genetic defect that causes it. Unfortunately, gene therapy is not yet possible. The next best solution is to block the formation of dihydrotestosterone. Most researchers believe that this hormone is responsible for the progressive miniaturization of
follicles, which is the hallmark of androgenic
Alopecia. One of the actions of Crinagen is to block the activity of 5 alpha-reductase and, thereby, its ability to convert testosterone into dihydrotestosterone. In this manner, it reduces the amount of
DHT within the scalp. Reducing the amount of DHT reduces its miniaturizing effects on the
It also reduces the amount of injury it causes to the
follicle and also the extent of the immune response targeted to the
follicle. The creators of this product recommend the use of immunosuppressant agents in conjunction because, although
it may reduce the quantity of DHT, it does not completely reverse the damage to
follicles that has already occurred. These damaged follicles incite an immune system inflammatory response which can damage them even further.
The use of immunosuppressants can reduce this inflammatory reaction and, thus, subsequent damage to
follicles. In Conquering Hair Loss there is a complete discussion of the
inflammation/thinning connection. There is also a complete discussion of the different types of immunosuppressive agents.
(Typically Lasts 4-6 Weeks)
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It differs from other topical scalp preparations in that it is sold by itself, without an accompanying shampoo.
This means it is much much cheaper than most similar treatment
packages out there. Effective shampoos already exist and are
easy to obtain. I would recommend ones that are anti-inflammatory, such as Nizoral
which is available in 1% form in every Grocery Store shampoo
section. There is also a 2% form available by prescription
which has shown results on balding similar to 2% minoxidil, but in
any case, we have heard nothing but good reports about Nizoral shampoo.
It is a very effective immunosuppressant.
To prevent the inflammatory reaction to the scalp from occurring , the source of damage to the
follicles must be eliminated. Again,
DHT is the source of this injury, causing the progressive miniaturization of
follicles. It contains both Zinc and Saw Palmetto, which reduce the production of
DHT. In addition, it contains vitamin B6, which has been shown to work in concert with zinc to inhibit 5 alpha-reductase.
Nutritive blood flow to the
follicles is another factor that has been shown to regulate regrowth.
It also contains both Polysorbate 20 and Niacin, which cause the release of histamine. Histamine mediates the immediate (vascular) response of inflammation thought to be beneficial for
In addition, it contains Ginkgo Biloba, which has been shown to affect the amount of blood delivered to the
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